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Amphetamine is thought to inhibit monoamine oxidase, whereas the power of amphetamine and its metabolites to inhibit many P450 isozymes as well as other enzymes has not been sufficiently elucidated. In vitro experiments with human microsomes show small inhibition of CYP2D6 by amphetamine and minimal inhibition of CYP1A2, 2D6, and 3A4 by a number of